Coincident In Vitro Analysis of DNA-PK-Dependent and -Independent Nonhomologous End Joining
In mammalian cells, DNA double-strand breaks (DSBs) are primarily repaired by nonhomologous end joining (NHEJ).The current model suggests that the Ku 70/80 heterodimer binds to DSB ends and recruits DNA-PKcs to form the active DNA-dependent protein kinase, DNA-PK.Subsequently, XRCC4, DNA ligase IV, XLF and arrethe bush balm most likely, other unide